Tianeptine

What is Tianeptine? 

Tianeptine (Sodium) is an atypical tricyclic antidepressant. Its mechanism of action is completely different from traditional antidepressants. It was once mischaracterized as a “selective serotonin reuptake enhancer,” but modern research has revealed a more complex mode of action. It was originally developed by a French pharmaceutical company and is approved for the treatment of major depressive episodes in some European, Asian, and Latin American countries.

Applications:

1. Historical Theory (Revised):

   • Initially, it was mistakenly classified as a “selective serotonin reuptake enhancer,” which is the direct opposite of how SSRIs (e.g., Fluoxetine/Prozac) work as reuptake inhibitors. It was thought to work by enhancing serotonin reuptake to modulate the glutamatergic system.

2. Modern Understanding (Mainstream View):

   • Current research indicates that Tianeptine’s primary mechanism involves modulating the glutamatergic system and enhancing neuroplasticity.

   • Modulates Glutamate Transmission: It normalizes the activity of glutamate, the brain’s primary excitatory neurotransmitter, which is often dysregulated in depression and chronic stress.

   • Promotes Neuroplasticity: It stimulates the expression of Brain-Derived Neurotrophic Factor (BDNF), promoting synaptic plasticity and neurogenesis, thereby helping to reverse brain damage caused by stress or depression. This mechanism shares some similarities with ketamine.

   • Opioid System Activity: Its metabolites are potent agonists of the μ-opioid receptor. This explains its rapid anxiolytic and antidepressant effects but is also the direct cause of its addictive potential and abuse liability.

3. Main Efficacy:

   • Treatment of Major Depressive Disorder: Effectively alleviates depressive mood, anxiety (often co-morbid with depression), and psychomotor retardation.

   • Improves Cognitive Function: Some studies suggest it may improve cognitive impairment associated with depression.

   • Relatively Rapid Onset: Compared to traditional SSRIs, which can take weeks to work, Tianeptine may begin to show effects within a week.

Fuctions:

• Dosage Forms:

  • Coated Tablets: Typically 12.5mg sodium salt tablets (e.g., Stablon®).

• Therapeutic Areas:

  • Psychiatry: Specifically used for the treatment of major depressive episodes in adults.

  • Dosage and Administration: Strictly follow medical advice. The typical dose is 12.5mg, three times daily (orally before meals). Self-increasing the dose is absolutely prohibited.

 💎Tianeptine COA  generally includes the following test items and standards:

TEST PARAMETER	SPECIFICATION	RESULT	METHOD
Appearance	White to off-white crystalline powder	Off-white crystalline powder	Visual
Identification (HPLC)	Complies with reference standard	Complies	HPLC
Assay (Purity)	98.0% - 102.0%	99.5%	HPLC
Loss on Drying	≤ 0.5%	0.2%	Eur. Ph. 2.2.32
Residue on Ignition	≤ 0.1%	0.05%	USP <281>
Heavy Metals (as Pb)	≤ 10 ppm	< 10 ppm	ICP-MS
Arsenic (As)	≤ 2 ppm	< 1 ppm	ICP-MS
Lead (Pb)	≤ 5 ppm	< 3 ppm	ICP-MS
Mercury (Hg)	≤ 1 ppm	< 0.5 ppm	ICP-MS
Cadmium (Cd)	≤ 1 ppm	< 0.5 ppm	ICP-MS
Related Substances			HPLC
∟ Individual impurity	≤ 0.5%	0.2%
∟ Total impurities	≤ 1.5%	0.8%
Microbial Limit
∟ Total Aerobic Count	≤ 1000 CFU/g	< 100 CFU/g	USP
∟ Yeast & Molds	≤ 100 CFU/g	< 10 CFU/g	USP
∟ E. coli	Absent in 1g	Absent	USP
∟ Salmonella	Absent in 10g	Absent	USP
Solubility (1% in water)	Clear solution	Clear, colorless solution	In-house M-001

♻️ FAQ

     Q: Do you support private label customization?
A: Yes! Full-service solutions:

• Formula customization (purity/dosage/form)

• Compliance packaging & labeling

• Global certifications (REACH, FDA, Halal)

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    Q: How is quality controlled?
A: 3-Stage QC Protocol:

1. Raw material screening (purity/heavy metals)

2. In-process monitoring

3. Batch COA with traceable LOT

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Q: What if issues arise post-purchase?
A: We guarantee:

• 72h response for quality claims

• Free reformulation support (within 6 months)

• Dedicated account manager

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Q: Payment & delivery terms?
A:

• Payment: T/T, L/C, PayPal

• Shipping: Global DDP/DAP (MOQ 25kg)

• Stock: 1,000+ metric tons ready-to-ship