Stigmasterol

What is Stigmasterol? 

Stigmasterol is a naturally occurring, unsaturated plant sterol (phytosterol). It is a white or slightly yellow crystalline powder410 that is widely found in various plant sources, most notably soybeans, vegetable oils (like rapeseed oil, corn oil), nuts, seeds, and certain medicinal herbs149.

Chemically, it shares a similar core ring structure with cholesterol but differs in its side chain (it has an ethyl group at C24 and a double bond between C22 and C23)249. This structural difference is key to its unique biological activities and its poor absorption in the human intestine compared to cholesterol.

 

Applications:

1. Cholesterol Management & Cardiovascular Health:

   • ⚖️ Mechanism: Its structural similarity to cholesterol allows it to competitively inhibit the absorption of dietary cholesterol in the intestines.

   • Effect: Significantly reduces levels of Low-Density Lipoprotein Cholesterol (LDL-C – “bad” cholesterol). Studies show daily intake of 1.5-3 grams of plant sterols (including stigmasterol) can lower LDL-C by 7-12%17.

   • Outcome: Contributes to reduced risk of atherosclerosis and supports overall cardiovascular health.

2. Anti-Inflammatory Properties:

   • 🌡️ Mechanism: Stigmasterol can modulate inflammatory pathways, notably by inhibiting the production and release of key pro-inflammatory signaling molecules (cytokines) such as TNF-α (Tumor Necrosis Factor-alpha) and IL-6 (Interleukin-6).

   • Effect: Helps reduce chronic inflammation, a root cause of many diseases. Studies suggest potential benefits in conditions like arthritis and inflammatory skin disorders.

3. Antioxidant Activity:

   • 🛡️ Mechanism: Stigmasterol acts as a free radical scavenger.

   • Effect: Protects cells and tissues (including skin cells) from oxidative stress damage caused by reactive oxygen species (ROS). This helps combat cellular aging and may contribute to reducing the risk of certain chronic diseases.

4. Skin Barrier Enhancement & Skin Health:

   • 💆 Mechanism: When applied topically or consumed, stigmasterol supports the synthesis of lipids (ceramides, fatty acids) within the stratum corneum (the outermost skin layer).

   • Effect: Strengthens the skin barrier function, improving skin hydration, reducing transepidermal water loss (TEWL), and alleviating symptoms of dryness and sensitivity. It shows promise in managing conditions like eczema and dermatitis17. Its anti-inflammatory and antioxidant effects further contribute to calming irritated skin and protecting against environmental damage.

5. Potential Immunomodulatory & Other Effects:

   • 🛡️ Some research indicates stigmasterol may have immune-modulating effects, though the exact mechanisms require further validation.

   • 🔬 Emerging preclinical studies (mainly in vitro and animal models) explore its potential role in supporting prostate health and even anti-cancer activities (e.g., against ovarian, prostate, breast, colon cancer lines), but robust clinical evidence in humans is still needed.

   • 💊 It serves as a crucial precursor (starting material) in the semi-synthesis of important steroid hormones like progesterone, as well as Vitamin D3.

Fuctions:

1. • Cholesterol-Lowering Formulas: A core ingredient in supplements specifically designed to support healthy cholesterol levels and cardiovascular function (often combined with other plant sterols/stanols like beta-sitosterol).

   • Heart Health Blends: Incorporated into broader heart health supplements for its combined cholesterol management, antioxidant, and anti-inflammatory effects.

   • Anti-Inflammatory & Antioxidant Support: Used in supplements targeting overall wellness, joint health, and healthy aging due to its ability to combat inflammation and oxidative stress.

   • General Wellness: Added to multivitamins or functional foods/beverages as a bioactive component promoting holistic health.

2. Cosmetic & Personal Care Ingredients:

   • Moisturizers & Emollients: Valued for its ability to reinforce the skin barrier, enhance hydration, and improve skin softness and smoothness. Ideal for dry, sensitive, and mature skin formulations (creams, lotions, serums).

   • Anti-Aging & Repair Products: Leverages its antioxidant properties to protect skin from free radical damage (pollution, UV stress) and its role in supporting skin repair mechanisms.

   • Soothing & Anti-Irritant Products: Utilizes its anti-inflammatory effects to calm redness, irritation, and reactive skin (e.g., in products for eczema-prone skin, after-shave, post-procedure care).

   • Hair Care Products: Sometimes included for potential scalp health benefits and emollient properties.

3. Pharmaceutical Intermediates:

   • 🧪 Synthesis of Steroids: An essential starting material (precursor) in the industrial semi-synthesis of progesterone (a vital hormone) and adrenocortical hormones (like cortisone). This is a significant industrial use.

   • Vitamin D3 Synthesis: Also serves as a precursor in the synthesis of Vitamin D3 (Cholecalciferol)

 💎Stigmasterol COA generally includes the following test items and standards:

Property	Value/Description	Relevance
CAS No.	83-48-7	Unique chemical identifier
Molecular Formula	C₂₉H₄₈O	Defines chemical composition
Appearance	White to off-white crystalline powder	Cosmetic/Pharma grade suitability
Solubility	Insoluble in water; Soluble in organic solvents	Formulation guidance
Melting Point	165-167°C (lit.)4	Quality/purity indicator
Purity	Available up to ≥99%5	Critical for efficacy in end products

♻️ FAQ

     Q: Do you support private label customization?
A: Yes! Full-service solutions:

• Formula customization (purity/dosage/form)

• Compliance packaging & labeling

• Global certifications (REACH, FDA, Halal)

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    Q: How is quality controlled?
A: 3-Stage QC Protocol:

1. Raw material screening (purity/heavy metals)

2. In-process monitoring

3. Batch COA with traceable LOT

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Q: What if issues arise post-purchase?
A: We guarantee:

• 72h response for quality claims

• Free reformulation support (within 6 months)

• Dedicated account manager

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Q: Payment & delivery terms?
A:

• Payment: T/T, L/C, PayPal

• Shipping: Global DDP/DAP (MOQ 25kg)

• Stock: 1,000+ metric tons ready-to-ship