Spermidine trihydrochloride

What is Spermidine trihydrochloride? 

Chemical Nature

Basic Properties:
Spermidine Trihydrochloride (CAS No.: 334-50-9) is a stable hydrochloride salt form of the naturally occurring polyamine spermidine. Its molecular formula is C₇H₁₉N₃·3HCl, with a molecular weight of 254.63 g/mol. It appears as a white crystalline powder.

Solubility:
It is highly soluble in water (50 mg/mL) and DMSO (25 mg/mL), but insoluble in ethanol, making it suitable for formulation development.

Biological Origin and Mechanism

Spermidine naturally occurs in various foods (such as legumes, grains, and dairy products) and in human tissues. However, its levels decline with age, necessitating external supplementation.

Core Mechanism:
Spermidine promotes autophagy—a cellular self-renewal process that degrades and recycles damaged components to maintain cellular homeostasis. Additionally, it negatively modulates NMDA receptors, providing neuroprotective effects.

Applications:

1. Anti-Aging and Lifespan Extension

Cellular Renewal:
Induces autophagy to clear senescent cells and slow organ functional decline. A human cohort study (n = 829) showed that individuals with high spermidine intake had a 40.5% lower all-cause mortality, equivalent to being 5.7 years biologically younger.

Telomere Protection:
Supports the stability of telomeres (chromosome ends), thereby reducing the accumulation of cellular aging markers.

2. Neuroprotection and Cognitive Enhancement

Inhibition of NMDA Receptor Overactivation:
Reduces excitotoxicity and improves the survival rate of brain cells.

Clinical Correlation:
Studies suggest spermidine may lower the risk of Alzheimer’s disease and enhance memory and cognitive flexibility.

3. Antioxidant and Anti-Inflammatory Effects

Reduction of Oxidative Stress:
Significantly inhibits hydrogen peroxide (H₂O₂) and superoxide anion (O₂⁻·), while enhancing superoxide dismutase (SOD) activity.

Systemic Protection:
Alleviates chronic inflammation and supports cardiovascular health, such as by reducing the risk of atherosclerosis.

4. Skin Repair and Anti-Aging

Epidermal Regeneration:
Promotes autophagic clearance of damaged collagen, stimulates fibroblast proliferation, and reduces the appearance of wrinkles.

Barrier Enhancement:
Maintains the structural stability of lipids in the stratum corneum, improving the skin’s moisture retention.

5. Metabolic and Immune Regulation

Mitochondrial Function Optimization:
Boosts cellular energy metabolism and helps alleviate post-exercise muscle fatigue.

Immune Cell Activation:
Enhances the activity of natural killer (NK) cells, improving the body’s ability to eliminate pathogens.

Fuctions:

1. Dietary Supplement Ingredient

Anti-Aging Capsules:
Recommended dosage is 5–10 mg/day. Often combined with NMN (Nicotinamide Mononucleotide) or Resveratrol for synergistic effects.

Sports Supplements:
Promotes muscle recovery and can be formulated together with Branched-Chain Amino Acids (BCAAs).

Neurohealth Products:
Combined with Phosphatidylserine (PS) to enhance blood-brain barrier permeability and neuroprotective efficacy.

2. Cosmetic Ingredient

Formulation Type	Recommended Concentration	Functional Target
Anti-aging serum	0.1–0.5%	Activates skin autophagy, reduces wrinkle depth
Antioxidant lotion	0.05–0.2%	Neutralizes free radicals, brightens skin tone
Repair cream	0.3–1%	Strengthens skin barrier, soothes redness/sensitivity

3. Research and Pharmaceutical Applications

Autophagy Research Tool:
Used in studies of cancer and neurodegenerative disease mechanisms.

Drug Carrier:
Leverages its cationic properties to encapsulate nucleic acid-based drugs, such as siRNA.

 💎Spermidine trihydrochloridet COA generally includes the following test items and standards:

Test Item	Specification	Result	Method
Appearance	White crystalline powder	Conforms	Visual inspection
Identification (IR/NMR)	Consistent with reference standard	Conforms	IR & ¹H-NMR
Assay (on dry basis)	≥ 98.0%	99.2%	HPLC
Water Content	≤ 1.0%	0.4%	Karl Fischer
pH (1% in water)	4.5–6.5	5.3	pH Meter
Heavy Metals (Pb, As, Hg, Cd)	≤ 10 ppm	< 5 ppm	ICP-MS
Residue on Ignition	≤ 0.5%	0.2%	USP <281>
Solubility	Soluble in water and DMSO; insoluble in ethanol	Conforms	Qualitative
Microbial Limits	Total Plate Count ≤ 1000 CFU/g
Yeast & Mold ≤ 100 CFU/g	Conforms	USP <61>, <62>

♻️ FAQ

     Q: Do you support private label customization?
A: Yes! Full-service solutions:

• Formula customization (purity/dosage/form)

• Compliance packaging & labeling

• Global certifications (REACH, FDA, Halal)

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    Q: How is quality controlled?
A: 3-Stage QC Protocol:

1. Raw material screening (purity/heavy metals)

2. In-process monitoring

3. Batch COA with traceable LOT

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Q: What if issues arise post-purchase?
A: We guarantee:

• 72h response for quality claims

• Free reformulation support (within 6 months)

• Dedicated account manager

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A:

• Payment: T/T, L/C, PayPal

• Shipping: Global DDP/DAP (MOQ 25kg)

• Stock: 1,000+ metric tons ready-to-ship