PQQ (Pyrroloquinoline Quinone)

What is PQQ (Pyrroloquinoline Quinone)? 

PQQ (Pyrroloquinoline Quinone), also known as Pyrroloquinoline Quinone, is a naturally occurring “vitamin-like” antioxidant with unique redox activity. First discovered in bacteria, it is widely present in plants, mammals, and human tissues. Humans cannot synthesize PQQ endogenously and must obtain it through diet or supplements.

⚙️ Key Properties:

1. Mitochondrial Activator: Stimulates new mitochondria generation (mitochondrial biogenesis) by activating the PGC-1α signaling pathway, enhancing cellular energy production efficiency.

2. Potent Antioxidant: 100× stronger than vitamin C in neutralizing free radicals and reducing oxidative stress damage.

3. Water-Soluble Molecule: Highly bioavailable and capable of crossing the blood-brain barrier to support brain cells.

🍃 Natural Food Sources:

• High-content foods: Kiwi, papaya, green peppers, parsley, natto, green tea, spinach.

• Human tissue levels: ~0.8-5.8 ng/g; abundant in breast milk (supports infant development).

Applications:

🧠 Cognitive Enhancement & Neuroprotection

• Improved Cognitive Function: Clinical trials show 20mg/day PQQ supplementation significantly enhanced memory, reaction speed, and executive function in elderly subjects after 12 weeks.

• Neuroprotective Mechanisms:

  • Promotes Nerve Growth Factor (NGF) synthesis, supporting neuron survival/repair.

  • Inhibits β-amyloid aggregation, reducing Alzheimer’s risk.

  • Minimizes brain damage after ischemic stroke.

🔋 Cellular Energy Boost & Anti-Fatigue

• Mitochondrial Regeneration: Activates SIRT1/PGC-1α pathway, increasing mitochondrial quantity/function and ATP production.

• Fatigue Reduction: Human trials reported 30% higher daytime energy and improved sleep quality after 8 weeks of PQQ supplementation.

❤️ Cardiovascular & Metabolic Health

• Cardioprotection: Animal studies confirm PQQ reduces myocardial infarction area and improves heart function, outperforming drugs like metoprolol.

• Metabolic Regulation:

  • Enhances insulin sensitivity, lowers blood glucose and LDL cholesterol.

  • Suppresses lipogenic enzymes, reducing visceral fat and obesity risk.

🛡️ Anti-Inflammatory & Systemic Protection

• Systemic Anti-Inflammation: Lowers CRP, IL-6, and other inflammatory markers.

• Organ Protection:

  • Liver: Reduces alcohol-induced damage and transaminase levels.

  • Bones: Activates osteoblasts, preventing osteoporosis (comparable to estrogen).

  • Eyes: Protects retinal ganglion cells and delays macular degeneration.

⏳ Anti-Aging & Longevity

• Longevity Protein Activation: Upregulates SIRT1/3/6 pathways, enhancing cellular stress resistance and repair.

• Lifespan Extension: Extends nematode lifespan by 30% in animal studies.

Fuctions:

Benefit Category	Mechanism	Research Support	Target Users
Cognitive Boost	Promotes NGF synthesis	Human clinical trials	Elderly/mental workers
Energy Enhancement	Increases mitochondria & ATP	Human/animal studies	Fatigued/athletic groups
Cardioprotection	Reduces heart damage, improves lipids	Animal models	Cardio-metabolic risk groups
Antioxidant/Anti-inflammatory	Scavenges free radicals, lowers CRP	Cell/human studies	Chronic inflammation sufferers
Anti-Aging	Activates Sirtuins, repairs DNA	Animal/cell research	Longevity seekers

1. Dietary Supplements

   • Cognitive health formulas: Often combined with CoQ10 (synergistically enhances memory/focus).

   • Energy support: Used for chronic fatigue syndrome and exercise recovery (e.g., athlete supplements).

2. Functional Foods/Beverages

   • Added to energy bars/meal replacements for “cellular anti-aging + metabolic boost” claims.

3. Medical Adjuvant Uses

   • Cardiovascular implants: PQQ-PAMAM coatings on titanium devices reduce thrombosis/inflammation.

   • Neurodegenerative prevention: Investigated as a neuroprotectant for Parkinson’s/Alzheimer’s.

 💎PQQ COA generally includes the following test items and standards:

Product Name	Pyrroloquinoline quinone (PQQ)
Catalog Number	M18151
CAS Number	72909-34-3
Molecular Formula	C₁₄H₆N₂O₈
Molecular Weight	330.21 g/mol
Appearance	Solid (red-brown to dark brown crystal)
Purity	≥99.0% (HPLC verified)
Solubility	1 mg/mL in water (25°C)
Storage	Powder: -20°C (3 years), 4°C (2 years)
H-NMR	Consistent with structure

♻️ FAQ

     Q: Do you support private label customization?
A: Yes! Full-service solutions:

• Formula customization (purity/dosage/form)

• Compliance packaging & labeling

• Global certifications (REACH, FDA, Halal)

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    Q: How is quality controlled?
A: 3-Stage QC Protocol:

1. Raw material screening (purity/heavy metals)

2. In-process monitoring

3. Batch COA with traceable LOT

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Q: What if issues arise post-purchase?
A: We guarantee:

• 72h response for quality claims

• Free reformulation support (within 6 months)

• Dedicated account manager

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Q: Payment & delivery terms?
A:

• Payment: T/T, L/C, PayPal

• Shipping: Global DDP/DAP (MOQ 25kg)

• Stock: 1,000+ metric tons ready-to-ship