Memantine

What is Memantine ? 

Memantine is a synthetic compound known as an NMDA receptor antagonist, commonly used in scientific research and cognitive-support formulations. It interacts with glutamatergic neurotransmission by regulating excessive NMDA receptor activity, supporting healthy neuronal communication and synaptic function. Memantine is valued in nootropic and neuroscience fields for its neuroprotective profile, stability, and well-studied mechanism of action.

Memantine (chemical name: 3,5-dimethyltricyclo[3.3.1.13,7]decan-1-amine or 3,5-dimethyladamantan-1-amine) is a synthetic small molecule belonging to the NMDA (N-methyl-D-aspartate) receptor antagonist class of drugs . Its molecular formula is C₁₂H₂₁N, with a molecular weight of 179.31 g·mol⁻¹ . The commercially used form is typically Memantine Hydrochloride . It is a prescription medication first approved in the early 2000s and is now widely available as a generic drug .

Mechanism of Action: It acts as a low-affinity, uncompetitive antagonist at the NMDA receptor in the brain . By modulating the activity of the neurotransmitter glutamate, it is believed to protect nerve cells from overstimulation (excitotoxicity), which is thought to contribute to symptoms of Alzheimer’s disease.

Applications:

1. Nootropic & Cognitive-Support Formulations

Memantine is used as a raw ingredient in high-end cognitive-support products aimed at:

• Memory and learning support

• Focus and cognitive clarity

• Balanced glutamate activity

• Long-term brain function optimization

2. Neuroscience & Pharmacology Research

Widely applied as a standard compound in:

• Studies on NMDA receptor pathways

• Neuroprotection and excitotoxicity research

• Synaptic function and neuronal communication

• Neuropharmacology model development

3. Advanced Nutraceutical Formulations

Some manufacturers include Memantine in specialized brain-health blends targeting professionals, students, aging populations, and focus-driven applications.

• Symptomatic Treatment for Moderate to Severe Alzheimer’s Disease: Memantine is clinically proven to provide modest, symptomatic improvement for patients with moderate to severe Alzheimer’s disease . It can lead to small but statistically significant positive effects across several domains compared to a placebo:

  • Cognition: Improves the ability to think and remember, or slows the loss of these abilities .

  • Daily Function: Helps with the ability to perform normal daily activities .

  • Behavior and Mood: Can reduce neuropsychiatric symptoms such as agitation and improve overall mood .

• Adjunctive Therapy: For patients already taking an acetylcholinesterase inhibitor (e.g., donepezil), adding Memantine can provide limited additional clinical benefits for those with moderate to severe dementia .

• Generally Well-Tolerated Profile: It is known to be generally well-tolerated in the target patient population . Common side effects are typically mild and may include dizziness, headache, confusion, and constipation .

Fuctions:

1. NMDA Receptor Modulation

Memantine selectively modulates NMDA receptors, helping maintain balanced glutamate signaling essential for cognitive processes and neuronal health.

2. Supports Neuronal Protection

By regulating excessive excitatory stimulation, Memantine is widely used in research exploring neuroprotection and synaptic preservation.

3. Cognitive & Memory Support

Formulators and researchers use Memantine for its potential to assist in supporting cognitive performance, information processing, and mental clarity.

4. Promotes Synaptic Stability

Memantine may help maintain healthy synaptic activity, which is critical for communication between neurons and long-term brain function.

• Pharmaceutical Active Ingredient (API): Its primary and approved use is as the Active Pharmaceutical Ingredient (API) in formulations for the treatment of moderate to severe dementia of the Alzheimer’s type .

• Drug Formulations: It is formulated into various oral dosage forms for patient use, including:

  • Immediate-release tablets

  • Oral solution

  • Extended-release capsules

• Investigational Uses: Research has explored or continues to explore its potential in other neurological and psychiatric conditions, such as certain forms of dementia (e.g., vascular dementia), but these are not primary approved indications and evidence is less robust .

 💎 Memantine COA  generally includes the following test items and standards:

tem	Specification	Result
Appearance	White to off-white crystalline powder	Complies
Identification	Positive (HPLC/IR)	Complies
Assay (HPLC)	≥ 99.0%	99.3%
Sulphate Content	Conforms to standard	Complies
Specific Rotation	+XX° to +XX°	+XX°
Loss on Drying	≤ 1.0%	0.28%
Residue on Ignition	≤ 0.1%	0.02%
pH (1% solution)	XX – XX	XX
Heavy Metals	≤ 10 ppm	< 10 ppm
Lead (Pb)	≤ 2 ppm	< 2 ppm
Arsenic (As)	≤ 1 ppm	< 1 ppm
Mercury (Hg)	≤ 0.1 ppm	< 0.1 ppm
Cadmium (Cd)	≤ 1 ppm	< 1 ppm
Microbial Limits
Total Plate Count	≤ 1,000 cfu/g	< 100 cfu/g
Yeast & Mold	≤ 100 cfu/g	< 10 cfu/g
E. coli	Negative	Negative
Salmonella	Negative	Negative
Particle Size	95% pass 80 mesh (or customer standard)	Complies

♻️ FAQ

     Q: Do you support private label customization?
A: Yes! Full-service solutions:

• Formula customization (purity/dosage/form)

• Compliance packaging & labeling

• Global certifications (REACH, FDA, Halal)

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    Q: How is quality controlled?
A: 3-Stage QC Protocol:

1. Raw material screening (purity/heavy metals)

2. In-process monitoring

3. Batch COA with traceable LOT

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Q: What if issues arise post-purchase?
A: We guarantee:

• 72h response for quality claims

• Free reformulation support (within 6 months)

• Dedicated account manager

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A:

• Payment: T/T, L/C, PayPal

• Shipping: Global DDP/DAP (MOQ 25kg)

• Stock: 1,000+ metric tons ready-to-ship