Ergothioneine

What is Ergothioneine? (English Version)

Ergothioneine (EGT) is a naturally occurring, sulfur-containing amino acid derivative primarily found in mushrooms (e.g., shiitake, oyster), as well as in certain bacteria, grains, and animal tissues. It is renowned for its exceptional antioxidant, anti-inflammatory, and cellular protective properties, earning it the scientific nickname “Longevity Vitamin” due to its critical role in mitigating age-related damage.

Applications:

1. Cosmetic Ingredients

   • Anti-aging products: Creams/serums (0.1–0.5% recommended) to combat photoaging and preserve collagen.

   • Whitening products: Synergizes with vitamin C (e.g., 22% VC + ergothioneine) to inhibit melanogenesis.

   • Sun care repair: Enhances sunscreen photostability and repairs UV-induced cellular damage.

2. Dietary Supplements

   • Oral supplementation (safe dose: 1.31 mg/kg/day for adults) elevates ET levels in blood/tissues, preventing age-related diseases.

   • Target groups: Elderly, occupational high-oxidative-stress populations (e.g., radiation/pollution exposure).

3. Pharmaceutical & Health Products

   • Protects liver/kidneys against metabolic toxins (e.g., high-cholesterol diets, fibrotic inducers).

   • Improves cardiovascular health: Inhibits vascular endothelial oxidative damage, lowering atherosclerosis risks.

Fuctions:

• 1. Potent Antioxidant & Anti-inflammatory

     • Neutralizes free radicals, inhibits lipid peroxidation and protein oxidation, protecting cells from oxidative damage.

     • Reduces inflammatory factor expression, mitigates inflammation triggered by UV (UVA/UVB) and reactive oxygen species (ROS).
       （Outperforms CoQ10 and Idebenone with >30% higher lipid peroxidation inhibition）

  2. DNA Repair & Anti-photoaging

     • Absorbs UV (λmax 257nm), reduces UV-induced DNA damage, and accelerates cellular repair.

     • Activates PI3/Akt/Nrf2 signaling pathway in skin cells, boosting endogenous antioxidant enzymes to delay photoaging.

  3. Skin Brightening & Whitening

     • Inhibits tyrosinase activity (binding to enzymatic active sites), reducing melanin synthesis.

     • Clinical data: 0.3% concentration significantly decreases melanin index after 4 weeks, outperforming 7% vitamin C.

  4. Cross-Barrier Protection & Neuroprotection

     • Absorbed via specific transporter (OCTN1/SLC22A4), penetrates blood-brain barrier, and accumulates in brain tissue, eye lenses, and deep skin layers.

     • Slows neurodegeneration (e.g., Alzheimer’s, Parkinson’s) and reduces age-related cognitive impairment risks.

 💎Ergothioneine COA generally includes the following test items and standards:

Parameter	Specification	Result	Test Method
Appearance	White to off-white powder	White crystalline powder	Visual inspection
Identification (HPLC)	Matches reference standard	Complies	USP ⟨621⟩
Purity (HPLC)	≥99.0%	99.63%	ISO 17025 accredited HPLC
Water Content	≤0.5%	0.21%	Karl Fischer titration
Residue on Ignition	≤0.1%	0.05%	USP ⟨281⟩
Heavy Metals (as Pb)	≤10 ppm	<5 ppm	ICP-MS (USP ⟨232⟩/⟨233⟩)
Arsenic (As)	≤2 ppm	<1 ppm	ICP-MS
Residual Solvents	≤100 ppm (total)	Not detected	GC-FID (ICH Q3C)
Microbiological Tests
- Total Aerobic Count	≤100 CFU/g	<10 CFU/g	USP ⟨61⟩
- Yeast & Mold	≤10 CFU/g	<1 CFU/g	USP ⟨61⟩
- E. coli	Absent	Absent	USP ⟨62⟩
Specific Rotation	+115° to +120°	+118.5°	Polarimetry (20°C)

♻️ FAQ

     Q: Do you support private label customization?
A: Yes! Full-service solutions:

• Formula customization (purity/dosage/form)

• Compliance packaging & labeling

• Global certifications (REACH, FDA, Halal)

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    Q: How is quality controlled?
A: 3-Stage QC Protocol:

1. Raw material screening (purity/heavy metals)

2. In-process monitoring

3. Batch COA with traceable LOT

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Q: What if issues arise post-purchase?
A: We guarantee:

• 72h response for quality claims

• Free reformulation support (within 6 months)

• Dedicated account manager

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Q: Payment & delivery terms?
A:

• Payment: T/T, L/C, PayPal

• Shipping: Global DDP/DAP (MOQ 25kg)

• Stock: 1,000+ metric tons ready-to-ship