IDRA 21

What is IDRA 21 ? 

IDRA-21 is a synthetic nootropic compound belonging to the ampakine class, known for its ability to modulate AMPA receptors and enhance glutamatergic neurotransmission. It is widely used as a research compound and as a functional ingredient in cognitive-support formulations designed for improved memory, learning efficiency, alertness, and overall cognitive performance.

IDRA 21 (7-chloro-3-methyl-3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide) is a benzothiadiazine derivative and a positive allosteric modulator of the AMPA-type glutamate receptor. It is a chiral molecule, with the (+)-IDRA-21 being the active form. Its primary mechanism is to inhibit the desensitization of AMPA receptors, thereby strengthening glutamatergic synaptic transmission and facilitating long-term potentiation (LTP), a cellular process crucial for learning and memory.

Applications:

• Potent Cognitive Enhancement: In preclinical studies, IDRA 21 has demonstrated significant pro-cognitive and memory-enhancing effects. It has been shown to potently reverse cognitive impairments induced by substances like alprazolam or scopolamine, with a reported potency approximately 10 to 30 times greater than that of aniracetam, a well-known racetam nootropic.
• Long Duration of Action: A key feature is its prolonged effect. Research in non-human primates indicates that a single oral administration can produce cognitive improvements that are maintained for up to 48 hours.
• Potential for Age-Related Cognitive Support: Studies have shown that IDRA 21 can improve task accuracy in both young and aged subjects, supporting its potential relevance for cognitive disorders associated with aging.
• Neuroscientific Research: It is primarily used as a standard and well-characterized pharmacological tool to study AMPA receptor function, synaptic plasticity (like LTP), and the mechanisms of learning and memory.
• Drug Discovery & Development: IDRA 21 serves as a prototype or lead compound in the research and development of novel AMPA receptor modulators (ampakines) for potential therapeutic applications in cognitive disorders.
• Nootropic Research Compound: Within the research community focused on cognitive enhancement, it is recognized as a potent experimental nootropic agent for preclinical studies.

Fuctions:

1. AMPA Receptor Modulation

IDRA-21 acts as a positive allosteric modulator of AMPA receptors, increasing synaptic transmission and neuronal communication.

2. Enhances Memory & Learning

Research suggests that IDRA-21 may strengthen long-term potentiation (LTP), supporting the formation and retention of new information.

3. Improves Cognitive Processing Speed

By boosting excitatory neurotransmission, IDRA-21 may contribute to quicker mental responses, better concentration, and increased mental clarity.

4. Supports Wakefulness & Alertness

IDRA-21 may help promote alertness and reduce mental fatigue, making it relevant in focus and productivity formulations.

5. Long-Lasting Cognitive Support

IDRA-21 is known for its extended duration of action compared to many other nootropic compounds in the ampakine category.

 💎 IDRA 21 COA  generally includes the following test items and standards:

tem	Specification	Result
Appearance	White to off-white crystalline powder	Complies
Identification	Positive (HPLC/IR)	Complies
Assay (HPLC)	≥ 99.0%	99.3%
Sulphate Content	Conforms to standard	Complies
Specific Rotation	+XX° to +XX°	+XX°
Loss on Drying	≤ 1.0%	0.28%
Residue on Ignition	≤ 0.1%	0.02%
pH (1% solution)	XX – XX	XX
Heavy Metals	≤ 10 ppm	< 10 ppm
Lead (Pb)	≤ 2 ppm	< 2 ppm
Arsenic (As)	≤ 1 ppm	< 1 ppm
Mercury (Hg)	≤ 0.1 ppm	< 0.1 ppm
Cadmium (Cd)	≤ 1 ppm	< 1 ppm
Microbial Limits
Total Plate Count	≤ 1,000 cfu/g	< 100 cfu/g
Yeast & Mold	≤ 100 cfu/g	< 10 cfu/g
E. coli	Negative	Negative
Salmonella	Negative	Negative
Particle Size	95% pass 80 mesh (or customer standard)	Complies

♻️ FAQ

     Q: Do you support private label customization?
A: Yes! Full-service solutions:

• Formula customization (purity/dosage/form)

• Compliance packaging & labeling

• Global certifications (REACH, FDA, Halal)

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    Q: How is quality controlled?
A: 3-Stage QC Protocol:

1. Raw material screening (purity/heavy metals)

2. In-process monitoring

3. Batch COA with traceable LOT

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Q: What if issues arise post-purchase?
A: We guarantee:

• 72h response for quality claims

• Free reformulation support (within 6 months)

• Dedicated account manager

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Q: Payment & delivery terms?
A:

• Payment: T/T, L/C, PayPal

• Shipping: Global DDP/DAP (MOQ 25kg)

• Stock: 1,000+ metric tons ready-to-ship