Agomelatine

What is Agomelatine ? 

Agomelatine is a compound that acts as a melatonin receptor agonist (MT1 and MT2) and a 5-HT2C serotonin receptor antagonist. Primarily developed as an antidepressant, it is now gaining attention in the nutraceutical and supplement industry for its dual role in regulating circadian rhythms and mood.

Applications:

1. Primary Benefits:

• Circadian Rhythm Regulation & Sleep Improvement: Synchronizes the sleep-wake cycle, promotes natural sleep onset, and is particularly beneficial for individuals with sleep onset difficulties or delayed sleep phase patterns.

• Mood Enhancement & Antidepressant Activity: Helps alleviate symptoms of low mood, anxiety, and depression by increasing the release of key neurotransmitters (norepinephrine and dopamine) in the prefrontal cortex. Improvement in sleep often precedes and contributes to mood elevation.

• Generally Favorable Tolerance Profile: Associated with a relatively lower incidence of common side effects like daytime drowsiness, weight gain, or sexual dysfunction compared to some traditional agents.

2. Main Applications:

• Pharmaceutical (Prescription Drug): Used for the treatment of Major Depressive Disorder (MDD) in adults, especially when accompanied by sleep disturbances.

• Nutraceutical/Dietary Supplement Ingredient: Serves as a functional component in formulations designed to support sleep quality, regulate circadian rhythms, and aid in mood management and mild, situational stress relief. This is a key area for promotion as an ingredient supplier.

3. Typical Product Positioning:

• Natural Circadian Rhythm Modulator

• Core Ingredient for Mood & Sleep Support Formulas

• Premium Ingredient for Stress/Anxiety Relief Supplements

4. Important Notes (Must be included in promotional materials):

• Dosage: The typical clinical dosage is 25-50mg per day. Dosage in supplement formulations must comply strictly with the regulations of the target market.

• Safety: Liver function monitoring is advised. Promotional materials should recommend consumers (especially those with liver conditions or alcohol users) consult a healthcare professional.

• Regulatory Compliance: It is crucial to verify the regulatory status of Agomelatine as a supplement ingredient in your target markets (e.g., USA, EU, Southeast Asia). In some regions, it may be approved as a prescription-only medicine and not permitted in general dietary supplements.

Fuctions:

1. Used for:

• Neuroscience research

• Emotional and mood-related models

• Circadian rhythm and sleep mechanism studies

• Receptor modulation experiments

• Psychological and behavioral research models

2. Pharmacological activity research

Commonly used in:

• Melatonin receptor modeling studies

• Serotonin receptor research

• Central nervous system (CNS) pharmacology research

3. Raw material evaluation

On certain B2B platforms or laboratory procurement channels, it is listed as:

• “API reference material”

• “Pharmaceutical intermediate”

• “Research chemical”

 💎Agomelatine COA  generally includes the following test items and standards:

Items	Standards	Results
Physical Analysis
Description	White Powder	Complies
Assay	99%	99.2%
Mesh Size	100 % pass 80 mesh	Complies
Ash	≤ 5.0%	2.85%
Loss on Drying	≤ 5.0%	2.85%
Chemical Analysis
Heavy Metal	≤ 10.0 mg/kg	Complies
Pb	≤ 2.0 mg/kg	Complies
As	≤ 1.0 mg/kg	Complies
Hg	≤ 0.1 mg/kg	Complies
Microbiological Analysis
Residue of Pesticide	Negative	Negative
Total Plate Count	≤ 1000cfu/g	Complies
Yeast&Mold	≤ 100cfu/g	Complies
E.coil	Negative	Negative
Salmonella	Negative	Negative

♻️ FAQ

     Q: Do you support private label customization?
A: Yes! Full-service solutions:

• Formula customization (purity/dosage/form)

• Compliance packaging & labeling

• Global certifications (REACH, FDA, Halal)

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    Q: How is quality controlled?
A: 3-Stage QC Protocol:

1. Raw material screening (purity/heavy metals)

2. In-process monitoring

3. Batch COA with traceable LOT

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Q: What if issues arise post-purchase?
A: We guarantee:

• 72h response for quality claims

• Free reformulation support (within 6 months)

• Dedicated account manager

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Q: Payment & delivery terms?
A:

• Payment: T/T, L/C, PayPal

• Shipping: Global DDP/DAP (MOQ 25kg)

• Stock: 1,000+ metric tons ready-to-ship