2,4-Diamino pyrimidine-3-oxide/kopexil

What is 2,4-Diamino pyrimidine-3-oxide/kopexil? 

2, 4-diaminopyrimidine oxide, commercially known as Aminexil, is widely used in its hair care products. Many cases of hair loss are often accompanied by “perifollar fibrosis”, that is, the collagen fibers around the hair follicle become thick and hard, which prevents the hair bulb from inserting into the deep dermis, resulting in the hair follicle being squeezed and unable to deliver nutrients, resulting in the hair becoming more and more fragile and soft. 2, 4-diaminopyrimidine is a relatively safe hair-fixing ingredient, which can effectively soften the cuticle around hair follicles and prolong the life of hair follicles. And no side effects, insist on use can achieve the purpose of long-term prevention of prolapse.

Applications:

Armenise (Kopexil) primarily works through the following mechanisms:

Aspect	Details
INCI Name	Diaminopyrimidine Oxide
Chinese Name	(Diaminopyrimidine Oxide)
Chemical Formula	C₄H₆N₄O
CAS Number	74638-76-9
Appearance	White or off-white crystalline powder
Solubility	Slightly soluble in water, soluble in ethanol, acetone, and other organic solvents (also described as highly water-soluble, with mild formulation properties)
Main Efficacy	Prevents hair loss, promotes hair growth, softens collagen, inhibits fibrosis, suppresses 5α-reductase activity
Applications	Shampoos, conditioners, scalp serums, hair milks, hair sprays, etc.
Recommended Dosage	General care: 0.5% - 2%; Intensive treatment: 2% - 5%

1. Softens Collagen: It softens hardened collagen around hair follicles, improving the follicular microenvironment, reducing pressure on follicles, thereby preventing premature hair loss and prolonging the hair growth phase.

2. Inhibits Fibrosis: By suppressing lysyl hydroxylase activity, it reduces excessive collagen accumulation and hardening, thereby delaying follicle miniaturization and creating a healthier environment for hair growth.

3. Suppresses 5α-Reductase: Some studies suggest it may inhibit 5α-reductase activity, thereby reducing the production of dihydrotestosterone (DHT), which contributes to androgenetic alopecia.

4. Improves Follicular Blood Circulation: It may share certain properties with minoxidil, helping to open potassium channels, improve microcirculation around follicles, and promote dermal papilla cell proliferation.

Fuctions:

• Shampoos

• Conditioners

• Scalp serums

• Hair milks

• Hair sprays

 💎 2,4-Diamino pyrimidine-3-oxide COA  generally includes the following test items and standards:

Test Item	Specification	Result	Method
Appearance	White to off-white crystalline powder	Off-white crystalline powder	Visual
Identification (HPLC)	Complies with reference standard	Complies	HPLC
Assay (Purity)	≥ 98.5%	99.2%	HPLC
Loss on Drying	≤ 0.5%	0.2%	Eur. Ph.
Residue on Ignition	≤ 0.1%	0.05%	USP
Heavy Metals (as Pb)	≤ 10 ppm	< 10 ppm	ICP-MS
Arsenic (As)	≤ 2 ppm	< 2 ppm	ICP-MS
Lead (Pb)	≤ 5 ppm	< 5 ppm	ICP-MS
Mercury (Hg)	≤ 1 ppm	< 1 ppm	ICP-MS
Cadmium (Cd)	≤ 1 ppm	< 1 ppm	ICP-MS
Total Microbial Count	≤ 1000 CFU/g	< 10 CFU/g	USP
Yeast & Molds	≤ 100 CFU/g	< 10 CFU/g	USP
Escherichia coli	Absent in 1g	Absent	USP
Staphylococcus aureus	Absent in 1g	Absent	USP
Pseudomonas aeruginosa	Absent in 1g	Absent	USP
Solubility (1% in Water)	Clear to slightly hazy solution	Clear, light yellow solution	In-house M-001

♻️ FAQ

     Q: Do you support private label customization?
A: Yes! Full-service solutions:

• Formula customization (purity/dosage/form)

• Compliance packaging & labeling

• Global certifications (REACH, FDA, Halal)

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    Q: How is quality controlled?
A: 3-Stage QC Protocol:

1. Raw material screening (purity/heavy metals)

2. In-process monitoring

3. Batch COA with traceable LOT

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Q: What if issues arise post-purchase?
A: We guarantee:

• 72h response for quality claims

• Free reformulation support (within 6 months)

• Dedicated account manager

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Q: Payment & delivery terms?
A:

• Payment: T/T, L/C, PayPal

• Shipping: Global DDP/DAP (MOQ 25kg)

• Stock: 1,000+ metric tons ready-to-ship