N-Acetyl-L-Cysteine Ethyl Ester Nacet (Nacet)

What is N-Acetyl-L-Cysteine Ethyl Ester Nacet(Nacet )? 

1. Core Definition and Chemical Structure:
NACET is an esterified derivative of the well-known antioxidant and detoxifying agent N-Acetyl-L-Cysteine (NAC). Its chemical structure can be understood as follows:

• NAC Foundation: It retains the core structure of NAC, where the cysteine amino acid is acetylated (Acetyl-), enhancing its stability and bioavailability.

• Ethyl Ester Bond (Ethyl Ester): This is the key modification. NACET features an added ethyl ester group (-COOCH₂CH₃). This modification significantly enhances its lipophilicity (oil solubility).

2. Key Differences from NAC: Why NACET?

• Cell Membrane Permeability: Cell membranes are lipid bilayers, meaning lipophilic substances penetrate more easily. Ordinary NAC is water-soluble and has low transmembrane absorption efficiency. In contrast, NACET’s lipophilicity allows it to cross cell membranes and the blood-brain barrier more easily and rapidly.

• Bioavailability: Once inside cells, intracellular esterases quickly hydrolyze NACET, releasing the biologically active L-cysteine and NAC. Thus, NACET is considered a prodrug, delivering these active substances to cells more efficiently.

• Stability: The ethyl ester structure may offer better chemical stability.

In simple terms, NACET is an “enhanced version” or “efficient delivery system” for NAC, designed to address NAC’s low absorption rate and bioavailability.

the raw material N-Acetyl-L-Cysteine Ethyl Ester (NACET) is a lipophilic derivative of NAC with higher cell membrane permeability and bioavailability. Its core efficacy lies in efficiently elevating levels of the “master antioxidant” glutathione, thereby exerting powerful antioxidant, liver-protective, neurosupportive, and detoxifying effects. Its primary applications are as an active ingredient in high-end health products, pharmaceutical R&D, and cosmetics.

Applications:

The efficacy of NACET is based on its ability to efficiently elevate intracellular glutathione (GSH) levels. Glutathione is the body’s most potent and critical endogenous antioxidant.

1. Efficiently Boosts Glutathione (GSH) Levels: This is its core功效. NACET provides the necessary cysteine building blocks for glutathione synthesis, significantly enhancing cellular antioxidant defense and helping neutralize free radicals and alleviate oxidative stress.

2. Potent Antioxidant Effects: Through direct and indirect (via GSH elevation) mechanisms, it protects cells (including brain, liver, and heart cells) from oxidative damage and delays cellular aging.

3. Liver Protection and Detoxification: Glutathione is a key molecule in the liver’s Phase II detoxification pathways. NACET effectively supports liver function, accelerating the metabolism and excretion of alcohol, drugs, environmental toxins, etc., and is often used to protect the liver from damage.

4. Neuroprotection and Brain Health: Due to its ability to efficiently cross the blood-brain barrier, NACET shows great potential in protecting the brain. It may help:

   • Combat neuroinflammation and oxidative stress.

   • Support mitochondrial function.

   • Have potential applications in adjunctive research and management of neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s).

5. Respiratory System Support: Like NAC, NACET also acts as a mucolytic agent, breaking disulfide bonds in phlegm and thinning viscous mucus, making it easier to expectorate and benefiting respiratory health.

6. Immune Support: Adequate glutathione levels are crucial for maintaining normal immune function and helping regulate inflammatory responses.

Fuctions:

1. Dietary Supplements and High-End Health Products:

• This is NACET’s primary use. It is formulated into capsules, tablets, or powders and marketed as a superior alternative to NAC for antioxidant and liver protection benefits.

• Target audiences include: those concerned about liver health, individuals seeking enhanced antioxidant defense, the elderly, and people exposed to high levels of environmental pollution or toxins.

2. Pharmaceutical R&D and Active Pharmaceutical Ingredients (APIs):

• As a prodrug, NACET is a key candidate compound for developing new hepatoprotective drugs, neuroprotective agents, and detoxifying drugs.

• Researchers are exploring its potential applications in treating various oxidative stress-related diseases.

3. Cosmetics and Skincare Products:

• Leveraging its potent antioxidant and anti-inflammatory properties, NACET is added to high-end skincare products.

• Its claimed benefits include: brightening skin tone (inhibiting melanin production), anti-aging (reducing free radical damage), anti-inflammatory effects, and repairing the skin’s own antioxidant system.

4. Research Reagents:

• In biochemistry, cell biology, and pharmacology laboratories, NACET is used as a tool compound to study mechanisms related to oxidative stress, apoptosis, glutathione metabolism, and more.

 💎 NACET COA  generally includes the following test items and standards

Item	Notes/Example
Product Name	N-Acetyl-L-cysteine ethyl ester (NACET)
CAS No.	59587-09-6
Molecular Formula	C₇H₁₃NO₃S
Molecular Weight	191.25
Appearance	Typically a white to off-white solid powder
Purity	≥ 98% (HPLC)
Solubility	DMSO: 50 mg/mL (261.44 mM); H₂O: ≥ 100 mg/mL (522.88 mM)
Water Content	≤ 0.5% (Karl Fischer method)
Heavy Metals	≤ 10 ppm (as Pb)
Related Substances/Impurities	Typically lists individual maximum impurity and total impurities
Storage Condition	Store at -20°C, keep dry, and protect from light

Product name	CAS No.	Purity
RU58841	154992-24-2	99%
4-DMA-7,8-DHF free base	1205548-00-0	99%
7,8-Dihydroxyflavone hydrate	38183-03-8	98%
5-Amino 1-MQ	42464-96-0	98%
9-Me-BC Synonyms: 9-Methyl-9H-beta-carboline	2521/7/5	99%
JBSNF-000088(6-Methoxynicotinamide)	7150-23-4	98%
GTS-21(DMXB-A)	148372-04-7	98%
Huperzine A	120786-18-7	98%
Idebenone	58186-27-9	99%
Ibudilast	50847-11-5	98%
Acetamoren	950841-87-9	99%
Phosphatidylserine(PS)	51446-62-9	30%,50%,70%,90%
Lemairamin(WGX-50)	29946-61-0	98%
Mitoquinone mesylate(Synonyms:MitoQ mesylate;MitoQ10 mesylate)	845959-50-4	99%
Trans-3,5-dimethoxystilbene-4′-O-β-D-glucopyranoside	50450-35-6	98%
	38967-99-6
Deazaflavin	26908-38-3	98%
3-Methyl-10-ethyl-Deazaflavin(TND-1128)	59997-14-7	98%
1,4-dihydronicotinaMide riboside(NRH)	19132-12-8	98%
Dehydrozingerone	1080-12-2	98%
Acetyl-Zingerone	113465-66-0	98%
Ubiquinol	992-78-9	98%
Cycloastragenol	84605-18-5	90-98%
CMS121  4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol	1353224-53-9	98%
Lithium orotate	5266-20-6	98%
Calcium Orotate	22454-86-0	98%
Spermidine trihydrochloride  98%	334-50-9	98%
Spermidine trihydrochloride 5%	334-50-9	5%
Spermidine	124-20-9	98%
Spermidine(Wheat Germ Extract)	124-20-9	1%,5%,20%
Spermine Tetrahydrochloride	306-67-2	98%%
Salidroside	10338-51-9	98%
ALA	868074-65-1	99%
Synonyms:5-Aminolevulinic acid phosphate
ATP	987-65-5	95%
Synonyms: Adenosine 5'-triphosphate disodium salt
HBT1	489408-02-8	99%
Synonyms:YDL223C
Ketone Ester(R-BHB)	1208313-97-6	98%
OEA	111-58-0	99%
Synonyms: Oleoylethanolamide
ODA  98%	301-02-0	98%
Synonyms: Oleamide
ODA  80-90%	301-02-0	80-90%
Synonyms: Oleamide
NACET Synonyms: N-Acetyl-L-cysteine ethyl ester	59587-09-6	98%
Melatonine	73-314	98%
Memantine Hd	41100-52-1	98%
Phenibut	1078-21-3	98%
5-Butylbenzene-1,3-diol	46113-76-2	98%
5-Heptylresorcinol	500-67-4	98%
Compound 7P	1890208-58-8	98%
ACA	35084-48-1	98%
Synonyms:1-(1-Adamantylcarbonyl) proline
Olivetol Synonyms:3,5-hydroxypentyl benzene)	500-66-3	99%
Calcium Alpha ketoglutarate	402726-78-7/71686-01-6	98%
Alpha ketoglutarate Magnesium	42083-41-0	98%
Calcium 2-Aminoethyl Phosphate	10389-08-9	98%
Copper Nicotinate	30827-46-4	98%
Glucoraphanin	21414-41-5	30%
5a-hydroxy Laxogenin	56786-63-1	99%
Nooglutyl	112193-35-8	99%
Fluorene Myristate	2595050-21-6	98%
Agomelatine	138112-76-2	98%
J-147	1146963-51-0	99%
Noopept	157115-85-0	100%
Synonyms: GVS-111
Galantamine Hydrobromide	1953/4/4	98%
IDRA21	22503-72-6	99%
ISRIB(Trans-isoMer)	1597403-47-8	99%
Trans-Isrib A17	1628478-15-8	99%
Unifiram	272786-64-8	99%
Alpha GPC 99%	28319-77-9	99%
Alpha GPC 50%	28319-77-9	50%
Sulbutiamine	3286-46-2	99%
Coluracetam	135463-81-9	99%
Sunifiram	314728-85-3	100%
Fasoracetam	110958-19-5	99%
Pramiracetam	68497-62-1	99%
Aniracetam	72432-10-1	99%
Nefiracetam	77191-36-7	99%
Oxiracetam	62613-82-5	99%
Piracetam	7491-74-9	99%
CDPC Synonyms:Citicoline	987-78-0	99%
Citicoline Sodium	33818-15-4	99%
PRL-8-53 (Phosphate)		99%
PRL-8-53  (HCL)	51352-87-5	99%
6-Paradol 98%	27113-22-0	98%
6-Paradol 50%	27113-22-0	50%
Glucoraphanin	21414-41-5	30%
Tianeptine acid	66981-73-5	99%
Tianeptine sodium	30123-17-2	99%
THM	1224690-84-9	99%
Synonyms: Tianeptine hemisulfate monohydrate
TEE	66981-77-9	98%
Synonyms:Tianeptine Ethyl Ester
Lauramine Laurate	14792-59-7	98%
N-Methyl-DL-Aspartic Acid	17833-53-3	98%
D-Cycloserine	68-41-7	99%
L-Theanine	34271-54-0	99%
Evodiamine	518-17-2	98%
Calcium Hopantenate Hemihydrate	17097-76-6	98%
NDLP Synonyms: N-Dodecanoyl-L-proline	58725-39-6	98%

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