Galanthamine hydrobromide

What is Galanthamine hydrobromide ? 

Galanthamine hydrobromide is a natural alkaloid extracted from plants of the Amaryllidaceae family (such as snowdrops, daffodils, and lycoris) and can also be synthesized artificially. It is a reversible acetylcholinesterase inhibitor primarily used for treating mild to moderate Alzheimer’s disease. It is recognized globally as one of the first-line drugs for this condition.

Applications:

1. Core Mechanism: Increasing Acetylcholine Levels

   • Acetylcholinesterase Inhibition: In the brain, the neurotransmitter acetylcholine (ACh) is crucial for learning, memory, and thinking. Alzheimer’s patients have significantly reduced ACh levels. Galantamine works by inhibiting acetylcholinesterase (the enzyme responsible for breaking down ACh), slowing its degradation, thereby increasing the concentration and activity of ACh in the brain and improving neural signal transmission.

   • Nicotinic Receptor Modulation: It also allosterically modulates presynaptic nicotinic acetylcholine receptors, enhancing the release of cholinergic neurotransmitters and further strengthening its therapeutic effects.

2. Main Efficacy

   • Improves Cognitive Function: Helps enhance patients’ memory, attention, orientation, and language abilities.

   • Slows Symptom Progression: Although it cannot cure Alzheimer’s disease, it can delay the progression of symptoms (such as cognitive and behavioral decline), helping patients maintain independence for a longer period.

   • Enhances Daily Functioning: Aids in improving patients’ ability to perform daily activities (e.g., dressing, eating, shopping).

Fuctions:

• Dosage Forms:

  • Oral Tablets: The most common form.

  • Capsules: Including extended-release capsules.

  • Oral Solution: Suitable for patients with difficulty swallowing.

• Therapeutic Areas:

  • Alzheimer’s Disease: Its primary and most extensive use, for treating mild to moderate cases.

  • Other Types of Dementia: Sometimes used for other cognitive disorders like vascular dementia, but its main indication is Alzheimer’s disease.

  • Historical Uses: In the past, it was used to reverse neuromuscular blockade caused by muscle relaxants and to treat sequelae of poliomyelitis in children.

 💎Galantamine Hydrobromide COA  generally includes the following test items and standards:

TEST PARAMETER	SPECIFICATION	RESULT	METHOD
Appearance	White to off-white crystalline powder	Off-white crystalline powder	Visual
Identification (HPLC)	Complies with reference standard	Complies	HPLC
Assay (Purity)	98.0% - 102.0%	99.5%	HPLC
Loss on Drying	≤ 0.5%	0.2%	Eur. Ph. 2.2.32
Residue on Ignition	≤ 0.1%	0.05%	USP <281>
Heavy Metals (as Pb)	≤ 10 ppm	< 10 ppm	ICP-MS
Arsenic (As)	≤ 2 ppm	< 1 ppm	ICP-MS
Lead (Pb)	≤ 5 ppm	< 3 ppm	ICP-MS
Mercury (Hg)	≤ 1 ppm	< 0.5 ppm	ICP-MS
Cadmium (Cd)	≤ 1 ppm	< 0.5 ppm	ICP-MS
Related Substances			HPLC
∟ Individual impurity	≤ 0.5%	0.2%
∟ Total impurities	≤ 1.5%	0.8%
Microbial Limit
∟ Total Aerobic Count	≤ 1000 CFU/g	< 100 CFU/g	USP
∟ Yeast & Molds	≤ 100 CFU/g	< 10 CFU/g	USP
∟ E. coli	Absent in 1g	Absent	USP
∟ Salmonella	Absent in 10g	Absent	USP
Solubility (1% in water)	Clear solution	Clear, colorless solution	In-house M-001

♻️ FAQ

     Q: Do you support private label customization?
A: Yes! Full-service solutions:

• Formula customization (purity/dosage/form)

• Compliance packaging & labeling

• Global certifications (REACH, FDA, Halal)

---

    Q: How is quality controlled?
A: 3-Stage QC Protocol:

1. Raw material screening (purity/heavy metals)

2. In-process monitoring

3. Batch COA with traceable LOT

---

Q: What if issues arise post-purchase?
A: We guarantee:

• 72h response for quality claims

• Free reformulation support (within 6 months)

• Dedicated account manager

---

Q: Payment & delivery terms?
A:

• Payment: T/T, L/C, PayPal

• Shipping: Global DDP/DAP (MOQ 25kg)

• Stock: 1,000+ metric tons ready-to-ship