Trigonelline Hydrochloride

What is Trigonelline Hydrochloride? 

Trigonelline Hydrochloride (Trigonelline HCl) is a biologically active alkaloid compound extracted from the seeds of the leguminous plant Fenugreek (Trigonella foenum-graecum). It is the hydrochloride salt form of trigonelline. This form typically offers higher stability, better water solubility, and a longer shelf life, making it an ideal functional raw material for use in health supplements and cosmetics.

It is a natural plant-based active ingredient that is gaining increasing attention in modern health products and skincare technology.

Applications:

1. Blood Glucose Management Support (Core Function)

   • Mechanism: Research indicates that trigonelline can improve insulin sensitivity, promote glucose utilization in peripheral tissues (e.g., muscles), and may inhibit sugar absorption in the intestines. It also helps protect pancreatic beta-cells and stimulate insulin secretion.

   • Use: Formulated into dietary supplements aimed at regulating blood sugar and supporting the management of Type 2 diabetes. Often combined with other ingredients like Chromium, Zinc, and Bitter Melon Extract.

2. Lipid Metabolism Regulation

   • Mechanism: Helps reduce levels of total cholesterol and triglycerides in the blood, potentially by activating the AMPK pathway to regulate lipid metabolism.

   • Use: Used in health products designed to support cardiovascular health and lower blood lipids.

3. Neuroprotection & Brain Health

   • Mechanism: Trigonelline can be converted into Niacin (Vitamin B3) in the body,参与细胞能量代谢 (participating in cellular energy metabolism). Studies show it has the potential to protect nerve cells, resist oxidative stress, and inhibit neuroinflammation, which may be beneficial in delaying cognitive decline.

   • Use: Used in developing nootropic supplements to improve memory, focus, and support long-term brain health.

4. Anti-inflammatory & Antioxidant Properties

   • Mechanism: As a natural alkaloid, it can scavenge free radicals and reduce inflammatory responses in the body.

   • Use: Serves as a supporting ingredient in comprehensive anti-aging and immune-boosting formulations.

Fuctions:

1. Hair Growth Promotion & Anti-Hair Loss (Star Application)

   • Mechanism: This is one of its most notable functions. Research shows that trigonelline effectively inhibits the activity of the 5-alpha-reductase enzyme, thereby reducing the conversion of testosterone into dihydrotestosterone (DHT), which causes hair follicle miniaturization. It also stimulates dermal papilla cells and prolongs the hair growth phase (Anagen Phase), providing more nutrients to the follicle.

   • Use: Widely used in anti-hair loss shampoos, hair serums, scalp treatments, and scalp nourishing tonics. It is a core active ingredient in natural anti-hair loss formulations.

2. Skin Anti-Aging & Antioxidant

   • Mechanism: Neutralizes free radicals, protecting skin cells from oxidative damage and reducing the degradation of collagen and elastin caused by UV exposure and environmental stressors.

   • Use: Used in anti-aging serums, creams, and eye creams to help smooth fine lines and improve skin elasticity.

3. Anti-inflammatory & Soothing

   • Mechanism: Reduces skin inflammation and alleviates redness and irritation.

   • Use: Suitable for sensitive skin care, soothing and calming products (e.g., after-sun care), and acne care products to calm the skin.

4. Whitening & Brightening

   • Mechanism: Preliminary research indicates it may interfere with melanin production by inhibiting tyrosinase activity.

   • Use: Can be added as a supporting ingredient in whitening essences, lotions, and products aimed at lightening hyperpigmentation.

 💎 Trigonelline Hydrochloride generally includes the following test items and standards:

Parameter	Specification	Test Result	Method
Appearance	Light yellow to off-white fine powder	Complies	Visual
Odor	Characteristic	Complies	Olfactory
Mesh Size	100% through 80 mesh	Complies	Sieve Analysis
Melting Point	297℃ - 298℃	Complies	USP
Solubility	Soluble in DMSO, ethanol; almost insoluble in water	Complies	USP <
dentification	Complies with Reference Standard	Complies	HPLC , TLC/UV
Genistein Purity	≥ 98.0%	99.2%	HPLC
Water (Loss on Drying)	≤ 1.0% - 6.0%	0.5%	USP
Total Ash	≤ 1.0%	0.3%	USP
∙ Lead (Pb)	≤ 3 ppm	<1 ppm	ICP-MS
∙ Arsenic (As)	≤ 2 ppm	<0.5 ppm	ICP-MS
∙ Cadmium (Cd)	≤ 1 ppm	<0.1 ppm	ICP-MS
∙ Mercury (Hg)	≤ 0.1 ppm	<0.05 ppm	ICP-MS
Solvent Residues	Meets Eur. Ph. 7.0 24	Complies	GC
Total Plate Count	≤ 1000 CFU/g	< 100 CFU/g	USP
Yeast & Mold	≤ 100 CFU/g	< 10 CFU/g	USP
E. coli	Negative	Negative	USP
Salmonella	Negative	Negative	USP

♻️ FAQ

     Q: Do you support private label customization?
A: Yes! Full-service solutions:

• Formula customization (purity/dosage/form)

• Compliance packaging & labeling

• Global certifications (REACH, FDA, Halal)

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    Q: How is quality controlled?
A: 3-Stage QC Protocol:

1. Raw material screening (purity/heavy metals)

2. In-process monitoring

3. Batch COA with traceable LOT

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Q: What if issues arise post-purchase?
A: We guarantee:

• 72h response for quality claims

• Free reformulation support (within 6 months)

• Dedicated account manager

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Q: Payment & delivery terms?
A:

• Payment: T/T, L/C, PayPal

• Shipping: Global DDP/DAP (MOQ 25kg)

• Stock: 1,000+ metric tons ready-to-ship