Equol

What is Equol? 

Equol is a bioactive metabolite derived from the fermentation of soy isoflavones (e.g., daidzein) by gut microbiota. Its chemical name is 4',7-isoflavandiol, with the molecular formula C₁₅H₁₄O₃.

• Unique Origin: Only 30%-50% of Asians naturally produce Equol due to specific gut bacteria; others require external supplementation.

• Stereoisomerism: S-Equol (the primary bioactive form) exhibits high selective affinity for estrogen receptor β (ERβ) (ERβ:ERα ≈ 50:1), ensuring superior efficacy and safety.

 

Applications:

(1) Menopausal Symptom Relief

• Reduces hot flashes and night sweats: Clinical trials show 58.7% decrease in hot flash frequency with 10mg/day S-Equol over 12 weeks.

• Stabilizes mood and improves sleep via ERβ modulation.

(2) Antioxidant & Anti-Inflammatory Effects

• Neutralizes free radicals and inhibits lipid peroxidation (stronger than precursor isoflavones).

• Suppresses neuroinflammation by blocking TLR-4/NF-κB/NLRP3 pathways.

(3) Bone Health Support

• Increases bone density, particularly for postmenopausal women combating osteoporosis.

(4) Skin Health Enhancement

• Boosts collagen synthesis, hydration, and elasticity while reducing photoaging signs.

(5) Neuroprotection & Potential Anti-Cancer Properties

• Inhibits breast (MDA-MB-231) and prostate cancer cell proliferation by downregulating MMP-2.

• Protects against Aβ toxicity and mitochondrial dysfunction linked to Alzheimer’s/Parkinson’s.

Fuctions:

Industry	Product Examples	Function
Nutraceuticals	Capsules, tablets, liquids	Menopausal support, bone health, sleep aid
Functional Foods	Powders, fermented beverages	Antioxidant, hormonal balance
Cosmetics	Serums, creams, eye care	Anti-aging, moisturizing, elasticity
Pharmaceuticals	Neuroprotective/cancer R&D Multi-target chronic disease intervention

• High Bioavailability: ~5x greater absorption than soy isoflavones; 7-8 hour half-life.

• Natural & Clinically Validated: Fermented from non-GMO soy germ (patented strains); supported by 10+ global human trials.

• Certified Compliance: NSF GMP, TDS, COA, and MSDS available.

 💎Equol COA generally includes the following test items and standards:

Test Item	Specification	Result	Test Method
Appearance	White to off-white crystalline powder	Complies	Visual
Identification	Complies with reference standard (HPLC/UV)	Complies	HPLC
Assay (Purity)	≥ 98.0%	99.52%	HPLC
S-Equol Enantiomer	≥ 98.0% of total Equol	99.1%	Chiral HPLC
Loss on Drying	≤ 1.0%	0.25%	Eur. Ph.
Residue on Ignition	≤ 0.2%	0.08%	Eur. Ph.
Heavy Metals (as Pb)	≤ 10 ppm	<5 ppm	ICP-MS
Arsenic (As)	≤ 2 ppm	<1 ppm	ICP-MS
Cadmium (Cd)	≤ 1 ppm	<0.5 ppm	ICP-MS
Mercury (Hg)	≤ 0.5 ppm	<0.1 ppm	ICP-MS
Lead (Pb)	≤ 3 ppm	<1 ppm	ICP-MS
Total Aerobic Microbial Count	≤ 1000 CFU/g	120 CFU/g	USP
Total Yeast & Mold	≤ 100 CFU/g	<10 CFU/g	USP
E. Coli	Negative	Negative	USP
Salmonella	Negative	Negative	USP
Solvent Residues	Complies with ICH Q3C	Complies	GC

♻️ FAQ

     Q: Do you support private label customization?
A: Yes! Full-service solutions:

• Formula customization (purity/dosage/form)

• Compliance packaging & labeling

• Global certifications (REACH, FDA, Halal)

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    Q: How is quality controlled?
A: 3-Stage QC Protocol:

1. Raw material screening (purity/heavy metals)

2. In-process monitoring

3. Batch COA with traceable LOT

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Q: What if issues arise post-purchase?
A: We guarantee:

• 72h response for quality claims

• Free reformulation support (within 6 months)

• Dedicated account manager

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Q: Payment & delivery terms?
A:

• Payment: T/T, L/C, PayPal

• Shipping: Global DDP/DAP (MOQ 25kg)

• Stock: 1,000+ metric tons ready-to-ship