Urolithin A

What is Urolithin A? 

Urolithin A is a bioactive compound metabolized by gut microbiota from natural polyphenols (e.g., ellagitannins) found in pomegranates, strawberries, walnuts, and raspberries. Its unique value lies in activating mitophagy (clearing damaged mitochondria and promoting regeneration), thereby optimizing cellular energy metabolism and delaying aging.

Applications:

Test Parameter	Acceptance Criteria	Test Method
Appearance	White or off-white powder; free of visible impurities	Visual inspection
Identification	Polygonal/round granules (2–35 μm) under microscope; blue-black color with iodine (fades on heating)	Microscopy; Chemical reaction
Acidity (pH)	4.5–7.0	Potentiometric titration
Loss on Drying	≤14.0% (130°C, 90 min)	Oven drying
Residue on Ignition	≤0.6%	Incineration
Microbial Limits	TAMC ≤10³ CFU/g; TYMC ≤10² CFU/g; E. coli absent	Microbial culture
Heavy Metals	≤20 ppm	Colorimetry
Sulfur Dioxide Residue	≤0.004%	Distillation titration

1. Anti-Aging & Cellular Renewal

• Reverses immune aging: Restores function of aged hematopoietic stem cells, enhances immune cell activity, and improves infection/cancer resistance (mouse studies show immune recovery to youthful levels).

• Neuroprotection: Crosses the blood-brain barrier, reduces amyloid-beta plaques in Alzheimer’s models, and improves cognition.

2. Muscle Function Enhancement

• Clinical trials: Daily 500mg supplementation increases muscle strength by 12% in older adults and significantly improves endurance (6-minute walk test).

3. Metabolism & Weight Management

• Activates brown fat, promotes white fat browning, reduces visceral fat, and enhances insulin sensitivity.

4. Skin Health & Photoprotection

• Key cosmetic advantages:
  ✅ Anti-photoaging: 1% topical cream reduces UVB-induced skin damage and inhibits collagen degradation.
  ✅ Antioxidant & anti-inflammatory: Lowers oxidative stress and inflammatory markers (e.g., IL-6), improves wrinkle depth and skin hydration.

5. Anti-Cancer Potential

• Synergizes with immunotherapy to expand T memory stem cells (Tscm), enhancing anti-tumor immunity (significantly suppresses tumor growth in colorectal cancer models).

Fuctions:

Application	Product Types	Scientific Basis
Nutraceutical Ingredient	Anti-aging capsules/sports supplements	Activates mitophagy, boosts muscle strength, metabolism & immunity
Cosmetic Ingredient	Anti-aging serums/sun repair products	Reduces photodamage, strengthens skin barrier & collagen synthesis
Functional Food Additive	Meal replacements/health beverages	Improves metabolic syndrome (obesity, insulin resistance)

Urolithin A’s Four Golden Benefits

• ✨ Cellular Anti-Aging: Triggers mitophagy, reverses stem cell aging

• 💪 Muscle Empowerment: 12% strength gain (clinically proven in 50+ adults)

• 🛡️ Immune Enhancement: Boosts T-cell anti-tumor activity, synergizes with immunotherapy

• 🔬 Skin Recovery: 1% concentration reduces wrinkles and blocks UV damage

 💎Urolithin A COA generally includes the following test items and standards:

Test Parameter	Specification	Test Method
Purity (HPLC)	≥97% or ≥98%	Reverse-phase HPLC
Appearance	Off-white to pale yellow powder	Visual inspection
Solubility	Soluble in DMSO, PG	Solubility test
Water Content	≤5.0%	Karl Fischer titration
Heavy Metals	≤10 ppm	ICP-MS
Residual Solvents	Complies with ICH Q3C	GC-FID
Microbial Limits	Absence of pathogens	USP <61>
Specific Rotation	-25° to -35° (c=1, MeOH)	Polarimetry

♻️ FAQ

     Q: Do you support private label customization?
A: Yes! Full-service solutions:

• Formula customization (purity/dosage/form)

• Compliance packaging & labeling

• Global certifications (REACH, FDA, Halal)

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    Q: How is quality controlled?
A: 3-Stage QC Protocol:

1. Raw material screening (purity/heavy metals)

2. In-process monitoring

3. Batch COA with traceable LOT

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Q: What if issues arise post-purchase?
A: We guarantee:

• 72h response for quality claims

• Free reformulation support (within 6 months)

• Dedicated account manager

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Q: Payment & delivery terms?
A:

• Payment: T/T, L/C, PayPal

• Shipping: Global DDP/DAP (MOQ 25kg)

• Stock: 1,000+ metric tons ready-to-ship