Chondroitin sulfate

What is Chondroitin sulfate?

Chondroitin sulfate is an acidic mucopolysaccharide naturally found in animal connective tissues, primarily extracted from shark, bovine, or porcine cartilage. Its core functions include maintaining tissue hydration, repairing damage, and regulating inflammatory responses.

Chondroitin sulfate is a versatile bioactive compound critical for joint health, cardiovascular protection, neural repair, and tissue engineering. Its efficacy amplifies in formulations (e.g., with glucosamine), and it demonstrates high safety. Future research may unlock its potential in oncology and regenerative medicine.

Applications:

1. Joint Protection & Osteoarthritis Relief
   • Mechanism: As a cartilage matrix component, it enhances cartilage hydration (absorbing up to 50× its weight in water), cushions joint impact, and inhibits collagenase activity to delay cartilage degeneration.
   • Clinical Effects:
     • Efficacy for mild-to-moderate osteoarthritis pain remains debated (some studies show no effect; others report functional improvement).
     • Combined with glucosamine: Significantly enhances efficacy (7–20% greater pain reduction) and reduces NSAID usage.
2. Cardiovascular Health Maintenance
   • Lipid-Lowering & Anti-Atherosclerosis: Clears lipoproteins/cholesterol from blood, reduces vascular lipid deposition, and inhibits thrombosis. Daily 2000mg supplementation lowers acute coronary risk (1.7% vs. 27% in control groups).
   • Anticoagulant Effect: Mild anticoagulant activity (1mg ≈ 0.45U heparin), suitable for atherosclerosis prevention.
3. Neurological & Sensory Repair
   • Neuropathic Pain Relief: Repairs damaged myelin sheaths, alleviating neuralgia/migraines.
   • Hearing Protection: Mitigates streptomycin/noise-induced hearing loss and tinnitus.
   • Dry Eye Treatment: In eye drops (e.g., 0.1% concentration), combined with hyaluronic acid to stabilize tear film and repair corneal epithelium.
4. Tissue Repair & Anti-Inflammation
   • Wound Healing: Accelerates fibroblast proliferation/migration, aiding surgical/chronic wound recovery.
   • Anti-Inflammatory Mechanism: Suppresses NF-κB pathway and pro-inflammatory cytokines (e.g., IL-1β, TNF-α), reducing arthritis/cystitis inflammation.
5. Other Bioactivities
   • Antioxidant & Antiviral: Scavenges free radicals and inhibits viral replication.
   • Antitumor Potential: Shark-derived chondroitin may suppress tumor growth via immunomodulation (research ongoing).

Fuctions:

1. Pharmaceuticals

   • Osteoarthritis Drugs: Oral tablets/capsules (e.g., Japan’s Chondroitin ZS, 1560mg daily).

   • Ophthalmic Products: Artificial tears, corneal repair membranes, and viscoelastic agents for cataract surgery (e.g., HA/CS composites).

   • Wound Dressings: Collagen-chondroitin scaffolds for tissue regeneration.

2. Nutraceuticals

   • Joint Health: Often combined with glucosamine, MSM, or collagen to enhance lubrication/repair.

   • Cardiovascular Support: Incorporated into lipid-lowering formulas to prevent atherosclerosis

3. Biomaterials

   • Tissue Engineering Scaffolds: Combined with collagen for cartilage/corneal regeneration.

   • Drug Carriers: Sustained-release vehicles (e.g., ciprofloxacin ocular delivery) for targeted therapy.

4. Cosmetics
   Utilized in moisturizers/anti-aging serums for enhanced skin hydration and elasticity.

 💎Chondroitin sulfate COA generally includes the following test items and standards:

Test Item	Specification	Test Result
Appearance	Off - white to Cream Powder	PASS
Clarity	0.35 Max at 420nm	PASS
Optical Rotation	minus 20.0° — minus 30.0°	-29.10°
Chondroitin Sulfate Content (CPC)	90% Min (O.D.B)	91.3%
Loss on Drying	10% Max	8.35%
PH Value	5.5 - 7.5	6.8
Bulk Density	0.6g/ml Min	0.61g/ml
Particle Size	100% through 80mesh	PASS
Protein Content	6.0% Max (Dried Basis)	5.25%
Residue on Ignition	20% - 30%	22.67%

♻️ FAQ

     Q: Do you support private label customization?
A: Yes! Full-service solutions:

• Formula customization (purity/dosage/form)

• Compliance packaging & labeling

• Global certifications (REACH, FDA, Halal)

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    Q: How is quality controlled?
A: 3-Stage QC Protocol:

1. Raw material screening (purity/heavy metals)

2. In-process monitoring

3. Batch COA with traceable LOT

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Q: What if issues arise post-purchase?
A: We guarantee:

• 72h response for quality claims

• Free reformulation support (within 6 months)

• Dedicated account manager

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Q: Payment & delivery terms?
A:

• Payment: T/T, L/C, PayPal

• Shipping: Global DDP/DAP (MOQ 25kg)

• Stock: 1,000+ metric tons ready-to-ship